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Sat Jul 4

• In Vitro - Comparative SAR Evaluations of Annonaceous Acetogenins for Pesticidal Activity - McLaughlin et al - 1996: The activities of 44 Annonaceous acetogenins, which were originally isolated by monitoring plant fractionations with the brine shrimp lethality test (BST), were evaluated in the yellow fever mosquito larvae microtiter plate (YFM) assay. The results clearly demonstrate that most acetogenins have pesticidal properties. The structure-acti vity relationships indicate that the compounds bearing adjacent bis-THF (tetrahydrofur an) rings with three hydroxyl groups are the most potent. Bullatacin (1) and trilobin (7) gave the best activities against YFM with LC50 values of 0·10 and 0·67 mg litre-1, respectively. Compounds showing LC50 values below 1·0 mg litre-1 in this assay are usually considered significant as new lead candidates for pesticidal development. In the BST, the corresponding LC50 values were 1·6×10-3 (1) and 9·7×10-3 (7) mg litre-1. Annonaceous acetogenins are known to act, at least in part, as potent inhibitors of mitochondrial NADH: ubiquinone oxidoreductase . © of SCI.
• In Vitro - Isolation of new bioactive annonaceous acetogenins from Rollinia mucosa via LC/MS - McLaughlin et al. - 1997: Reversed-phase high-performan ce liquid chromatography (RP-HPLC) fractionation, monitored by liquid chromatography /electrospray mass spectrometry (LC/ESI-MS), led to the isolation of two new bioactive annonaceous acetogenins, rollidecin C (1) and rollidecin D (2), from the bioactive aqueous methanol fraction of the leaves of Rollinia mucosa (Annonaceae). The structures were confirmed by analyses of the 1H and 13C NMR data. In addition, a known adjacent bis-tetrahydro furan (THF) acetogenin, desacetyluvari cin (3), was isolated from this plant for the first time utilizing the LC/ESI-MS monitoring approach. Compound 1 exhibited selective cytotoxicity toward the colon tumor cell line (HT-29), while 2 showed only borderline cytotoxicity in a panel of six human tumor cell lines.

Thu Jun 25

• East Coast Fertility - IVF, Infertility Specialists of Long Island (LI), New York (NY): Conceiving a New Era in Fertility Care. We have been selected to participate in the NY State DOH Grant. Please call us at (516) 939-BABY(2229) for an application. NY State Residents earning less than $200,000 are eligible for this subsidy. Affordable, Highest Quality IVF is now available at East Coast Fertility.

Wed Jun 17

• Conceive a Child in India: For people who are planning to undergo IVF treatments in India, medical tourism agencies are now available in United States, Europe and Canada. These agencies are open for clients who are willing to travel for an IVF treatment in India. They provide clients with affordable packages which are usually 40-50% cheaper than the U.S. cost.
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Tue Jun 16

• Affordable and Quality Infertility Treatment in India: India is renowned worldwide for its massive medical development and has been a consistent provider of world class healthcare eversince. One of its specialized procedures that has constantly draw in tourists from abroad is its excellent IVF procedures which aid couples to conceive a child.

Sat May 16

• In Vitro - Bistetrahydrof uranoid acetogenins from Rollinia sericea - Squamocin - Department of Chemistry, Virginia Commonwealth University, Richmond 23284-2006, US - 1995: Bistetrahydrof uranoid acetogenins from Rollinia sericea.Barnes JN, Schaneberg BT, Sneden AT. Department of Chemistry, Virginia Commonwealth University, Richmond 23284-2006, USA. PMID: 7480215 [PubMed - indexed for MEDLINE]
• In Vitro - Squamocin - Defined - Dr. Duke's Phytochemical and Ethnobotanical Databases - 2009: SQUAMOCIN -------------- -------------- -------------- -------------- -------------- ---------- Biological Activities Cytotoxic Dosage: L-1210 ED50=0.58 ppm; Reference: 478 Larvicide Dosage: 62-70 ppm diet; Reference: 478 Ovicide Dosage: 62-70 ppm diet; Reference: 478 Plant species with highest amount Annona squamosa L. -- Sugar-Apple, Sweetsop; in Seed; Please send questions and comments to: James A. Duke Green Farmacy Garden 8210 Murphy Road Fulton, MD 20759 or Mary Jo Bogenschutz (E-Mail: godwinm001@haw aii.rr.com)

Sun May 3

• In Vitro - Acetogenin - Researcher - Reynald Hocquemiller - France FR
• In Vitro - Squamocin - Aromin-A, an Annonaceous acetogenin from Annona cherimoya chirimoya cherimola - Kaohsiung Medical College, Taiwan TW - 1998: Abstract Chromatographi c fractionation of a MeOH extract from the stems of Annona cherimola led to the isolation of a new non-adjacent, bis-THF ring acetogenin (one THF ring being at C-4 and the other at C-16), aromin-A (1) along with the known cytotoxic acetogenin squamocin (2). The structures of these isolates were established by means of mass spectrometry and spectroscopic techniques. Yang-Chang Wu - Corresponding author. Tel.: +886-7-312-110 1 ext. 2197; fax: +886-7-311-477 3; email: yachwu@cc.kmc. edu.tw

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